Subsequent-generation sequencing (NGS) is a high-throughput technique for DNA sequencing that has largely outdated conventional first-generation sequencing strategies.
NGS has revolutionised the in vitro diagnostics (IVD) market by offering enhanced diagnostic capabilities and increasing the market scope.
The NGS market was valued at $1.9bn in 2023. The market will attain gross sales of $5.1bn by 2033, rising at a compound annual progress fee of 10.3% over the interval, in keeping with GlobalData forecasts.
The NGS market’s progress is fuelled by a mixture of unaddressed medical wants for more practical instruments in predicting, diagnosing, treating, and monitoring illnesses, together with the continued development of sequencing applied sciences for effectivity.
Through the forecast interval, income is anticipated to be primarily generated by high-throughput and medium-throughput NGS.
NGS permits for the simultaneous sequencing of tens of millions of fragments to generate a considerable amount of information in a single run, saving time and assets.
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Moreover, the price of sequencing has considerably diminished with the appearance of NGS, because it permits for the sequencing of huge quantities of DNA or RNA a lot faster than the beforehand used Sanger sequencing.
With decreased take a look at charges, GlobalData anticipates that demand for routine diagnostic procedures, together with most cancers panel testing and noninvasive prenatal testing, will develop.
NGS applied sciences have paved the way in which for personalised therapies, particularly within the area of oncology.
Physicians can sequence their sufferers’ tumours to match them to therapies designed to focus on the genetic alterations driving the tumour’s progress.
Automation will play an important function in facilitating the acceptance and integration of NGS into routine medical follow because the demand for diagnostic NGS testing will increase.
Using automation programs for library preparation and pattern evaluation will likely be instrumental in making certain the validity of the take a look at outcomes.
Automation additionally allows laboratories to consolidate a number of illness diagnostic exams right into a single system. This growth broadens the vary of diagnostic panel choices out there to clinicians and sufferers, enhancing the scope of diagnostic choices.
Illumina offers each sequencing by synthesis with its Solexa system and semiconductor sequencing with its Ion Torrent system whereas Thermo Fisher offers sequencing by ligation with its SOLiD/Life Applied sciences system.
Oxford Nanopore’s sequencing expertise has been used to develop a protocol for extremely correct complete human genome sequencing at scale.